Hyperactive mTORCI in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular re...
Hyperactive mTORCI in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling
About this item
Full title
Author / Creator
Lin, Susan M , Rue, Ryan , Mukhitov, Alexander R , Goel, Akansha , Basil, Maria C , Obraztsova, Kseniya , Babu, Apoorva , Crnkovic, Slaven , Ledwell, Owen A , Ferguson, Laura T , Planer, Joseph D , Nottingham, Ana N , Vanka, Kanth Swaroop , Smith, Carly J , Mi, Edward Cantu , Kwapiszewska, Grazyna , Morrisey, Edward E , Evans, Jillian F and Krymskaya, Vera P
Publisher
American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease caused by tuberous sclerosis complex 1/2 (TSC1/2) gene mutations in pulmonary mesenchymal cells, resulting in activation of the mechanistic target of rapamycin complex 1 (mTORC1). A subset of patients with LAM develop pulmonary vascular remodeling and pulmonary hypertension. Little...
Alternative Titles
Full title
Hyperactive mTORCI in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling
Authors, Artists and Contributors
Author / Creator
Rue, Ryan
Mukhitov, Alexander R
Goel, Akansha
Basil, Maria C
Obraztsova, Kseniya
Babu, Apoorva
Crnkovic, Slaven
Ledwell, Owen A
Ferguson, Laura T
Planer, Joseph D
Nottingham, Ana N
Vanka, Kanth Swaroop
Smith, Carly J
Mi, Edward Cantu
Kwapiszewska, Grazyna
Morrisey, Edward E
Evans, Jillian F
Krymskaya, Vera P
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracgeneralonefile_A786063952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracgeneralonefile_A786063952
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI172116
