The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant...
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
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Publisher
BioMed Central Ltd
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Language
English
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Publisher
BioMed Central Ltd
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Contents
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion within the huntingtin gene. Mutant huntingtin protein misfolds and accumulates within neurons where it mediates its toxic effects. Promoting mutant huntingtin clearance by activating macroautophagy is one approach for treating Huntington's disease...
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Full title
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
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TN_cdi_gale_infotracmisc_A232208121
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A232208121
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/1750-1326-5-26
