Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to [PrP....
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to [PrP.sup.Sc] accumulation
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Westaway, David , Genovesi, Sacha , Daude, Nathalie , Brown, Rebecca , Lau, Agnes , Lee, Inyoul , Mays, Charles E , Coomaraswamy, Janaky , Canine, Brenda , Pitstick, Rose , Herbst, Allen , Yang, Jing , Ko, Kerry W.S , Schmitt-Ulms, Gerold , DeArmond, Stephen J , McKenzie, Debbie , Hood, Leroy and Carlson, George A
Publisher
Public Library of Science
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English
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Public Library of Science
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Contents
During prion infections of the central nervous system (CNS) the cellular prion protein, [PrP.sup.C], is templated to a conformationally distinct form, [PrP.sup.Sc]. Recent studies have demonstrated that the Sprn gene encodes a GPI-linked glycoprotein Shadoo (Sho), which localizes to a similar membrane environment as [PrP.sup.C] and is reduced in th...
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Full title
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to [PrP.sup.Sc] accumulation
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TN_cdi_gale_infotracmisc_A273616544
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A273616544
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ISSN
1553-7366
DOI
10.1371/journal.ppat.1002391
