Microbial production of N-acetyl c/s-4-hydroxy-L-proline by coexpression of the Rhizobium L-proline...
Microbial production of N-acetyl c/s-4-hydroxy-L-proline by coexpression of the Rhizobium L-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1
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Publisher
Springer
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English
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Springer
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The proline analogue cis-4-hydroxy-L-proline (CHOP), which inhibits the biosynthesis of collagen, has been clinically evaluated as an anticancer drug, but its water solubility and low molecular weight limits its therapeutic potential since it is rapidly excreted. In addition, CHOP is too toxic to be practical as an anticancer drug, due primarily to...
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Full title
Microbial production of N-acetyl c/s-4-hydroxy-L-proline by coexpression of the Rhizobium L-proline cis-4-hydroxylase and the yeast N-acetyltransferase Mpr1
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TN_cdi_gale_infotracmisc_A337369562
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A337369562
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ISSN
0175-7598
DOI
10.1007/s00253-012-4204-z
