An integrin [β.sub.3]-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
An integrin [β.sub.3]-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
About this item
Full title
Author / Creator
Seguin, Laetitia , Kato, Shumei , Franovic, Aleksandra , Camargo, M. Fernanda , Lesperance, Jacqueline , Elliott, Kathryn C , Yebra, Mayra , Mielgo, Ainhoa , Lowy, Andrew M , Husain, Hatim , Cascone, Tina , Diao, Lixia , Wang, Jing , Wistuba, Ignacio I , Heymach, John V , Lippman, Scott M , Desgrosellier, Jay S , Anand, Sudarshan , Weis, Sara M and Cheresh, David A
Publisher
Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin [α.sub.v][β.sub.3] serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib. This was observed in vitro and in m...
Alternative Titles
Full title
An integrin [β.sub.3]-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
Authors, Artists and Contributors
Author / Creator
Kato, Shumei
Franovic, Aleksandra
Camargo, M. Fernanda
Lesperance, Jacqueline
Elliott, Kathryn C
Yebra, Mayra
Mielgo, Ainhoa
Lowy, Andrew M
Husain, Hatim
Cascone, Tina
Diao, Lixia
Wang, Jing
Wistuba, Ignacio I
Heymach, John V
Lippman, Scott M
Desgrosellier, Jay S
Anand, Sudarshan
Weis, Sara M
Cheresh, David A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A369064229
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A369064229
Other Identifiers
ISSN
1465-7392
DOI
10.1038/ncb2953
