Generation of aggregation prone N-terminally truncated amyloid [beta] peptides by meprin [beta] depe...
Generation of aggregation prone N-terminally truncated amyloid [beta] peptides by meprin [beta] depends on the sequence specificity at the cleavage site
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Publisher
BioMed Central Ltd
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English
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BioMed Central Ltd
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The metalloprotease meprin [beta] cleaves the Alzheimer's Disease (AD) relevant amyloid precursor protein (APP) as a [beta]-secretase reminiscent of BACE-1, however, predominantly generating N-terminally truncated A[beta]2-x variants. Herein, we observed increased endogenous sAPP[alpha] levels in the brains of meprin [beta] knock-out (ko) mice comp...
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Full title
Generation of aggregation prone N-terminally truncated amyloid [beta] peptides by meprin [beta] depends on the sequence specificity at the cleavage site
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TN_cdi_gale_infotracmisc_A443754331
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A443754331
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-016-0084-5
