53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged...
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
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eLife Science Publications, Ltd
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English
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Publisher
eLife Science Publications, Ltd
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Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis is consistently disturbed by centrosome loss. We identified 53BP1 and USP28 as es...
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Full title
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
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TN_cdi_gale_infotracmisc_A473245439
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A473245439
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.16270
