A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in...
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in human melioidosis
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Author / Creator
Chaichana, Panjaporn , Chantratita, Narisara , Brod, Florian , Koosakulnirand, Sirikamon , Jenjaroen, Kemajittra , Chumseng, Suchintana , Sumonwiriya, Manutsanun , Burtnick, Mary N , Brett, Paul J , Teparrukkul, Prapit , Limmathurotsakul, Direk , Day, Nicholas P. J , Dunachie, Susanna J and West, T. Eoin
Publisher
Public Library of Science
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Language
English
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Publisher
Public Library of Science
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Contents
Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinica...
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Full title
A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-[alpha] levels in human melioidosis
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TN_cdi_gale_infotracmisc_A493733447
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A493733447
Other Identifiers
ISSN
1935-2727
DOI
10.1371/journal.pntd.0005587
