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Circadian clock component REV-ERB[alpha] controls homeostatic regulation of pulmonary inflammation

Circadian clock component REV-ERB[alpha] controls homeostatic regulation of pulmonary inflammation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A543610692

Circadian clock component REV-ERB[alpha] controls homeostatic regulation of pulmonary inflammation

About this item

Full title

Circadian clock component REV-ERB[alpha] controls homeostatic regulation of pulmonary inflammation

Publisher

American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2018-06, Vol.128 (6), p.2281

Language

English

Formats

Publication information

Publisher

American Society for Clinical Investigation

More information

Scope and Contents

Contents

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERB[alpha] as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithe...

Alternative Titles

Full title

Circadian clock component REV-ERB[alpha] controls homeostatic regulation of pulmonary inflammation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A543610692

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A543610692

Other Identifiers

ISSN

0021-9738

DOI

10.1172/JCI93910

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