Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes
Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes
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Author / Creator
Han, Longsen , Ren, Chao , Li, Ling , Li, Xiaoyan , Ge, Juan , Wang, Haichao and Miao, Yi-Liang
Publisher
Nature Publishing Group
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Language
English
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Publisher
Nature Publishing Group
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Contents
Maternal obesity can impair embryo development and offspring health, yet the mechanisms responsible remain poorly understood. In a high-fat diet (HFD)-based female mouse model of obesity, we identified a marked reduction of Stella (also known as DPPA3 or PGC7) protein in oocytes. Starting with this clue, we found that the establishment of pronuclea...
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Full title
Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes
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Record Identifier
TN_cdi_gale_infotracmisc_A572557465
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A572557465
Other Identifiers
ISSN
1061-4036
DOI
10.1038/s41588-018-0055-6
