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Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphoma...

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphoma...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A573206214

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

About this item

Full title

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Publisher

Nature Publishing Group

Journal title

Nature Genetics, 2018, Vol.50 (12), p.1650

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

Subjects

More information

Scope and Contents

Contents

Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune activation that adversely affects survival.sup.1,2. T cell immunoglobulin mucin 3 (TIM-3) is a modulator of immune responses expressed on subgroups of T and innate immune cells. W...

Alternative Titles

Full title

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A573206214

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A573206214

Other Identifiers

ISSN

1061-4036

DOI

10.1038/s41588-018-0251-4

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