Subsets of exhausted CD8.sup.+ T cells differentially mediate tumor control and respond to checkpoin...
Subsets of exhausted CD8.sup.+ T cells differentially mediate tumor control and respond to checkpoint blockade
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Nature Publishing Group
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English
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Nature Publishing Group
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T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood. Here we show that such therapy acts on a specific subpopulation of exhausted CD8.sup.+ tumor-infiltrating lymphocytes (TILs)....
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Subsets of exhausted CD8.sup.+ T cells differentially mediate tumor control and respond to checkpoint blockade
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TN_cdi_gale_infotracmisc_A574731608
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A574731608
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ISSN
1529-2908
DOI
10.1038/s41590-019-0312-6
