RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
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Nature Publishing Group
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English
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Nature Publishing Group
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Mutations in the retinoblastoma (RB) tumour suppressor pathway are a hallmark of cancer and a prevalent feature of lung adenocarcinoma.sup.1-3. Although RB was the first tumour suppressor to be identified, the molecular and cellular basis that underlies selection for persistent RB loss in cancer remains unclear.sup.4-6. Methods that reactivate the...
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RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
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TN_cdi_gale_infotracmisc_A585606959
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A585606959
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ISSN
0028-0836
DOI
10.1038/s41586-019-1172-9
