Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
About this item
Full title
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
Author / Creator
Publisher
Nature Publishing Group
Journal title
Nature Structural and Molecular Biology, 2019, Vol.26 (4), p.315
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Cas12a is a bacterial RNA-guided nuclease used widely for genome editing and, more recently, as a molecular diagnostic. In bacteria, Cas12a enzymes can be inhibited by bacteriophage-derived proteins, anti-CRISPRs (Acrs), to thwart clustered regularly interspaced short palindromic repeat (CRISPR) adaptive immune systems. How these inhibitors disable...
Alternative Titles
Full title
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A593382317
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A593382317
Other Identifiers
ISSN
1545-9993
DOI
10.1038/s41594-019-0208-z
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