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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr...

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A601788874

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr.sup.348 phosphorylation

About this item

Full title

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr.sup.348 phosphorylation

Publisher

Springer

Journal title

Acta neuropathologica, 2019-10, Vol.138 (4), p.631

Language

English

Formats

Publication information

Publisher

Springer

More information

Scope and Contents

Contents

The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer's disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice either overexpressing human MAPT (TgMAPT) or both human MAPT and BIN1 (TgMAPT;TgBI...

Alternative Titles

Full title

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr.sup.348 phosphorylation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A601788874

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A601788874

Other Identifiers

ISSN

0001-6322

DOI

10.1007/s00401-019-02017-9

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