Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
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Publisher
BioMed Central Ltd
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Language
English
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Publisher
BioMed Central Ltd
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Scope and Contents
Contents
Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). We tested whether the induction of dNTP pool imbalance can affect HIV-1 replication in macrophages. For this test, we ind...
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Full title
Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
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TN_cdi_gale_infotracmisc_A604548162
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A604548162
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ISSN
1742-4690
E-ISSN
1742-4690
DOI
10.1186/s12977-019-0491-0
