STEEP mediates STING ER exit and activation of signaling
STEEP mediates STING ER exit and activation of signaling
About this item
Full title
STEEP mediates STING ER exit and activation of signaling
Author / Creator
Publisher
Nature Publishing Group
Journal title
Nature Immunology, 2020, Vol.21 (8), p.868
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
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More information
Scope and Contents
Contents
STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signaling, the mechanism that drives...
Alternative Titles
Full title
STEEP mediates STING ER exit and activation of signaling
Authors, Artists and Contributors
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Record Identifier
TN_cdi_gale_infotracmisc_A630328079
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A630328079
Other Identifiers
ISSN
1529-2908
DOI
10.1038/s41590-020-0730-5
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