MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effec...
MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects
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Nature Publishing Group
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English
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Nature Publishing Group
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Regenerative stem cell-like memory (T.sub.SCM) CD8.sup.+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces T.sub.SCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing mitochondrial b...
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MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects
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TN_cdi_gale_infotracmisc_A649637120
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A649637120
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ISSN
1529-2908
DOI
10.1038/s41590-020-00818-9
