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MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effec...

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effec...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A649637120

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

About this item

Full title

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

Publisher

Nature Publishing Group

Journal title

Nature Immunology, 2021, Vol.22 (1), p.53

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

More information

Scope and Contents

Contents

Regenerative stem cell-like memory (T.sub.SCM) CD8.sup.+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces T.sub.SCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing mitochondrial b...

Alternative Titles

Full title

MEK inhibition reprograms CD8.sup.+ T lymphocytes into memory stem cells with potent antitumor effects

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A649637120

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A649637120

Other Identifiers

ISSN

1529-2908

DOI

10.1038/s41590-020-00818-9

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