Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 producti...
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease
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Nature Publishing Group
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English
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Nature Publishing Group
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Aberrant inflammation in the CNS has been implicated as a major player in the pathogenesis of human neurodegenerative disease. We developed a new approach to derive microglia from human pluripotent stem cells (hPSCs) and built a defined hPSC-derived tri-culture system containing pure populations of hPSC-derived microglia, astrocytes, and neurons to...
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Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease
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TN_cdi_gale_infotracmisc_A655717700
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A655717700
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ISSN
1097-6256
DOI
10.1038/s41593-020-00796-z
