Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
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Nature Publishing Group
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English
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Nature Publishing Group
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Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development.sup.1,2. Cells that undergo WGD (WGD.sup.+ cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer vuln...
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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
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TN_cdi_gale_infotracmisc_A660665839
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A660665839
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ISSN
0028-0836
DOI
10.1038/s41586-020-03133-3
