Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications...
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
About this item
Full title
Author / Creator
Yun, Haiyang , Narayan, Nisha , Vohra, Shabana , Giotopoulos, George , Mupo, Annalisa , Madrigal, Pedro , Sasca, Daniel , Lara-Astiaso, David , Horton, Sarah J , Agrawal-Singh, Shuchi , Meduri, Eshwar , Basheer, Faisal , Marando, Ludovica , Gozdecka, Malgorzata , Dovey, Oliver M , Castillo-Venzor, Aracely and Wang, Xiaonan
Publisher
Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic approach to a murine allelic series that models the two most common mutations in AML: Flt3-ITD and Npm1c....
Alternative Titles
Full title
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A678008000
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A678008000
Other Identifiers
ISSN
1061-4036
DOI
10.1038/s41588-021-00925-9
