Small molecule inhibitors of [alpha]-synuclein oligomers identified by targeting early dopamine-medi...
Small molecule inhibitors of [alpha]-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
About this item
Full title
Author / Creator
Chen, Kevin S , Menezes, Krystal , Rodgers, Jarlath B , O'Hara, Darren M , Tran, Nhat , Fujisawa, Kazuko , Ishikura, Seiya , Khodaei, Shahin , Chau, Hien , Cranston, Anna , Kapadia, Minesh , Pawar, Grishma , Ping, Susan , Krizus, Aldis , Lacoste, Alix , Spangler, Scott , Visanji, Naomi P , Marras, Connie , Majbour, Nour K , El-Agnaf, Omar M. A , Lozano, Andres M , Culotti, Joseph , Suo, Satoshi , Ryu, William S , Kalia, Suneil K and Kalia, Lorraine V
Publisher
BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Background Parkinson's disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by [alpha]-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson's disease, but drug discovery is challenged by lack of in vivo models that recapitulate early stages of neurodegener...
Alternative Titles
Full title
Small molecule inhibitors of [alpha]-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Authors, Artists and Contributors
Author / Creator
Menezes, Krystal
Rodgers, Jarlath B
O'Hara, Darren M
Tran, Nhat
Fujisawa, Kazuko
Ishikura, Seiya
Khodaei, Shahin
Chau, Hien
Cranston, Anna
Kapadia, Minesh
Pawar, Grishma
Ping, Susan
Krizus, Aldis
Lacoste, Alix
Spangler, Scott
Visanji, Naomi P
Marras, Connie
Majbour, Nour K
El-Agnaf, Omar M. A
Lozano, Andres M
Culotti, Joseph
Suo, Satoshi
Ryu, William S
Kalia, Suneil K
Kalia, Lorraine V
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A686447986
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A686447986
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-021-00497-6
