SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation
SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation
About this item
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Author / Creator
Zeng, Juan , Jiang, Manxi , Wu, Xinghan , Diao, Feiyang , Qiu, Danhong , Hou, Xiaojing , Wang, Haichao , Li, Ling , Li, Chunling , Ge, Juan , Liu, Jiayin , Ou, Xianghong and Wang, Qiang
Publisher
John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
John Wiley & Sons, Inc
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Scope and Contents
Contents
SIRT4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species (ROS) level...
Alternative Titles
Full title
SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A707851316
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A707851316
Other Identifiers
ISSN
1474-9718
DOI
10.1111/acel.12789
