NMNAT2-mediated NAD+ generation is essential for quality control of aged oocytes
NMNAT2-mediated NAD+ generation is essential for quality control of aged oocytes
About this item
Full title
Author / Creator
Wu, Xinghan , Hu, Feifei , Zeng, Juan , Han, Longsen , Qiu, Danhong , Wang, Haichao , Ge, Juan , Ying, Xiaoyan and Wang, Qiang
Publisher
John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Advanced maternal age has been reported to impair oocyte quality; however, the underlying mechanisms remain to be explored. In the present study, we identified the lowered NAD[sup.+] content and decreased expression of NMNAT2 protein in oocytes from old mice. Specific depletion of NMNAT2 in mouse oocytes disturbs the meiotic apparatus assembly and...
Alternative Titles
Full title
NMNAT2-mediated NAD+ generation is essential for quality control of aged oocytes
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A707857496
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A707857496
Other Identifiers
ISSN
1474-9718
DOI
10.1111/acel.12955
