Tonic inhibition of the chloride/proton antiporter ClC-7 by PIP2 is crucial for lysosomal pH mainten...
Tonic inhibition of the chloride/proton antiporter ClC-7 by PIP2 is crucial for lysosomal pH maintenance
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eLife Science Publications, Ltd
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English
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eLife Science Publications, Ltd
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The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H.sup.+ ATPase, but other pathways for ion movement are required to dissipate the voltage generated by this process. ClC-7, a Cl.sup.-/H.sup.+ antiporter responsible for lysosom...
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Tonic inhibition of the chloride/proton antiporter ClC-7 by PIP2 is crucial for lysosomal pH maintenance
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TN_cdi_gale_infotracmisc_A708594967
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A708594967
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2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.74136
