Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumula...
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation
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Author / Creator
Ewers, Michael , Biechele, Gloria , Suárez-Calvet, Marc , Sacher, Christian , Blume, Tanja , Morenas-Rodriguez, Estrella , Deming, Yuetiva , Piccio, Laura , Cruchaga, Carlos , Kleinberger, Gernot , Shaw, Leslie , Trojanowski, John Q , Herms, Jochen , Dichgans, Martin , Brendel, Matthias , Haass, Christian and Franzmeier, Nicolai
Publisher
John Wiley & Sons, Inc
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Language
English
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Publisher
John Wiley & Sons, Inc
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Contents
Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased in AD; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (Aβ) accumulat...
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Full title
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation
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TN_cdi_gale_infotracmisc_A710569561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A710569561
Other Identifiers
ISSN
1757-4676
DOI
10.15252/emmm.202012308
