Copper ions, prion protein and A[beta] modulate Ca levels in central nervous system myelin in an NMD...
Copper ions, prion protein and A[beta] modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
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BioMed Central Ltd
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English
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BioMed Central Ltd
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As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in an NMDAR-dependent manner. Chelating Cu in the per...
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Full title
Copper ions, prion protein and A[beta] modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
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TN_cdi_gale_infotracmisc_A718177316
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A718177316
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ISSN
1756-6606
E-ISSN
1756-6606
DOI
10.1186/s13041-022-00955-2
