Gain- and Loss-of-Function ICFTR/I Alleles Are Associated with COVID-19 Clinical Outcomes
Gain- and Loss-of-Function ICFTR/I Alleles Are Associated with COVID-19 Clinical Outcomes
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Publisher
MDPI AG
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Language
English
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Publisher
MDPI AG
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Contents
Carriers of single pathogenic variants of the CFTR (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed CFTR as a bidirectional modulator of COVID-19 outcomes. Here, we demonstrate that the rare complex allele [G576V;R668C] is associat...
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Full title
Gain- and Loss-of-Function ICFTR/I Alleles Are Associated with COVID-19 Clinical Outcomes
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TN_cdi_gale_infotracmisc_A745409556
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A745409556
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells11244096
