Prominent tauopathy and intracellular [beta]-amyloid accumulation triggered by genetic deletion of c...
Prominent tauopathy and intracellular [beta]-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
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BioMed Central Ltd
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English
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BioMed Central Ltd
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Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-[beta] protein (A[beta]) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD in the development of A[beta] pathology and tauopathy in vivo. Methods CatD knockout (...
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Prominent tauopathy and intracellular [beta]-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
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TN_cdi_gale_infotracmisc_A788912332
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A788912332
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-024-01443-6
