Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and po...
Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14.sup.[DELTA]/+ mice hearts
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Public Library of Science
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English
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Public Library of Science
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Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by reversibly inhibiting the SERCA2a Ca.sup.2+ -reuptake pump. The R14[DELTA]-PLN mutation causes severe cardiomyopathy that is resistant to conventional treatment. Protein complexes and higher-order supercomplexes such as inter...
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Full title
Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14.sup.[DELTA]/+ mice hearts
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TN_cdi_gale_infotracmisc_A813480738
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A813480738
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0311203
