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Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
Author / Creator:Rudolph, Franziska ; Fink, Claudia ; Hüttemeister, Judith ; Kirchner, Marieluise ; Radke, Michael H. ; Lopez Carballo, Jacobo ; Wagner, Eva ; Kohl, Tobias ; Lehnart, Stephan E. ; Mertins, Philipp ; Gotthardt, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-06, Vol.11 (1), p.3133-3133, Article 3133
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Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2
Author / Creator:Zaglia, Tania ; Pianca, Nicola ; Borile, Giulia ; Da Broi, Francesca ; Richter, Claudia ; Campione, Marina ; Lehnart, Stephan E. ; Luther, Stefan ; Corrado, Domenico ; Miquerol, Lucile ; Mongillo, Marco
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4495-E4504
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Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes
Author / Creator:Rudolph, Franziska ; Hüttemeister, Judith ; da Silva Lopes, Katharina ; Jüttner, René ; Yu, Lily ; Bergmann, Nora ; Friedrich, Dhana ; Preibisch, Stephan ; Wagner, Eva ; Lehnart, Stephan E. ; Gregorio, Carol C. ; Gotthardt, Michael
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (50), p.25126-25136
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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes
Author / Creator:Weninger, Gunnar ; Pochechueva, Tatiana ; El Chami, Dana ; Luo, Xiaojing ; Kohl, Tobias ; Brandenburg, Sören ; Urlaub, Henning ; Guan, Kaomei ; Lenz, Christof ; Lehnart, Stephan E.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-06, Vol.12 (1), p.10387-10387, Article 10387
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Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice
Author / Creator:Shan, Jian ; Kushnir, Alexander ; Betzenhauser, Matthew J. ; Reiken, Steven ; Li, Jingdong ; Lehnart, Stephan E. ; Lindegger, Nicolas ; Mongillo, Marco ; Mohler, Peter J. ; Marks, Andrew R.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2010-12, Vol.120 (12), p.4388-4398
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Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies
Author / Creator:Hüttemeister, Judith ; Rudolph, Franziska ; Radke, Michael H ; Fink, Claudia ; Friedrich, Dhana ; Preibisch, Stephan ; Falcke, Martin ; Wagner, Eva ; Lehnart, Stephan E ; Gotthardt, Michael
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2024-12, Vol.13
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Remodeling of Ryanodine Receptor Complex Causes "Leaky" Channels: A Molecular Mechanism for Decreased Exercise Capacity
Author / Creator:Bellinger, Andrew M. ; Reiken, Steven ; Dura, Miroslav ; Murphy, Peter W. ; Deng, Shi-Xian ; Landry, Donald W. ; Nieman, David ; Lehnart, Stephan E. ; Samaru, Mahendranauth ; LaCampagne, Alain ; Marks, Andrew R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (6), p.2198-2202
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INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE
Author / Creator:Wehrens, Xander H.T. ; Lehnart, Stephan E. ; Marks, Andrew R.
Publisher:United States: Annual Reviews, Inc
Journal title:Annual review of physiology, 2005-01, Vol.67 (1), p.69-98
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Ryanodine Receptor/Calcium Release Channel PKA Phosphorylation: A Critical Mediator of Heart Failure Progression
Author / Creator:Wehrens, Xander H. T. ; Lehnart, Stephan E. ; Reiken, Steven ; Vest, John A. ; Wronska, Anetta ; Marks, Andrew R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (3), p.511-518
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Multiphoton Imaging of Ca2+ Instability in Acute Myocardial Slices from a RyR2R2474S Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia
Author / Creator:Borile, Giulia ; Zaglia, Tania ; E. Lehnart, Stephan ; Mongillo, Marco
Publisher:Basel: MDPI AG
Journal title:Journal of clinical medicine, 2021-06, Vol.10 (13), p.2821
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On the Adjacency Matrix of RyR2 Cluster Structures
Author / Creator:Walker, Mark A. ; Kohl, Tobias ; Lehnart, Stephan E. ; Greenstein, Joseph L. ; Lederer, W. J. ; Winslow, Raimond L.
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2015-11, Vol.11 (11), p.e1004521-e1004521
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Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
Author / Creator:Danielsen, Tore K. ; Manotheepan, Ravinea ; Sadredini, Mani ; Leren, Ida S. ; Edwards, Andrew G. ; Vincent, Kevin P. ; Lehnart, Stephan E. ; Sejersted, Ole M. ; Sjaastad, Ivar ; Haugaa, Kristina H. ; Stokke, Mathis K.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018, Vol.13 (11), p.e0207100-e0207100
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Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart
Author / Creator:Lehnart, Stephan E. ; Maier, Lars S. ; Hasenfuss, Gerd
Publisher:Boston: Springer US
Journal title:Heart failure reviews, 2009-12, Vol.14 (4), p.213-224
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CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy
Author / Creator:Schwenzer, Niko ; Teiwes, Nikolas K. ; Kohl, Tobias ; Pohl, Celine ; Giller, Michelle J. ; Lehnart, Stephan E. ; Steinem, Claudia
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-05, Vol.7 (1), p.620-11, Article 620
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Intensity matters: Ryanodine receptor regulation during exercise
Author / Creator:Kohl, Tobias ; Weninger, Gunnar ; Zalk, Ran ; Eaton, Philip ; Lehnart, Stephan E.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (50), p.15271-15272
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Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias
Author / Creator:Lehnart, Stephan E. ; Terrenoire, Cecile ; Reiken, Steven ; Wehrens, Xander H. T. ; Song, Long-Sheng ; Tillman, Erik J. ; Mancarella, Salvatore ; Coromilas, James ; Lederer, W. J. ; Kass, Robert S. ; Marks, Andrew R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7906-7910
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Protection from Cardiac Arrhythmia through Ryanodine Receptor-Stabilizing Protein Calstabin2
Author / Creator:Xander H. T. Wehrens ; Lehnart, Stephan E. ; Reiken, Steven R. ; Deng, Shi-Xian ; Vest, John A. ; Cervantes, Daniel ; Coromilas, James ; Landry, Donald W. ; Marks, Andrew R.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5668), p.292-296
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Ca2+/calmodulin‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak
Author / Creator:Dewenter, Matthias ; Seitz, Tilmann ; Steinbrecher, Julia H. ; Westenbrink, B. Daan ; Ling, Haiyun ; Lehnart, Stephan E. ; Wehrens, Xander H.T. ; Backs, Johannes ; Brown, Joan Heller ; Maier, Lars S. ; Neef, Stefan
Publisher:England: John Wiley & Sons, Inc
Journal title:ESC Heart Failure, 2024-08, Vol.11 (4), p.2191-2199
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The oxidation‐resistant CaMKII‐MM281/282VV mutation does not prevent arrhythmias in CPVT1
Author / Creator:Sadredini, Mani ; Manotheepan, Ravinea ; Lehnart, Stephan E. ; Anderson, Mark E. ; Sjaastad, Ivar ; Stokke, Mathis K.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Physiological reports, 2021-09, Vol.9 (18), p.e15030-n/a
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Enhancing Calstabin Binding to Ryanodine Receptors Improves Cardiac and Skeletal Muscle Function in Heart Failure
Author / Creator:Xander H. T. Wehrens ; Lehnart, Stephan E. ; Reiken, Steven ; van der Nagel, Roel ; Morales, Raymond ; Sun, Jie ; Cheng, Zhenzhuang ; Deng, Shi-Xiang ; de Windt, Leon J. ; Landry, Donald W. ; Marks, Andrew R. ; Olson, Eric N.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-07, Vol.102 (27), p.9607-9612
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Showing 1 to 20 of 41 results

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Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

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Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2

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Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes

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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

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Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

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Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

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Remodeling of Ryanodine Receptor Complex Causes "Leaky" Channels: A Molecular Mechanism for Decreased Exercise Capacity

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INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

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Ryanodine Receptor/Calcium Release Channel PKA Phosphorylation: A Critical Mediator of Heart Failure Progression

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Multiphoton Imaging of Ca2+ Instability in Acute Myocardial Slices from a RyR2R2474S Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia

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On the Adjacency Matrix of RyR2 Cluster Structures

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Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation

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Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart

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CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

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Intensity matters: Ryanodine receptor regulation during exercise

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Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias

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Protection from Cardiac Arrhythmia through Ryanodine Receptor-Stabilizing Protein Calstabin2

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Ca2+/calmodulin‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak

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The oxidation‐resistant CaMKII‐MM281/282VV mutation does not prevent arrhythmias in CPVT1

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Enhancing Calstabin Binding to Ryanodine Receptors Improves Cardiac and Skeletal Muscle Function in Heart Failure

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