Isolation of drugs active against mammalian prions using a yeast-based screening assay
Isolation of drugs active against mammalian prions using a yeast-based screening assay
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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We have developed a rapid, yeast-based, two-step assay to screen for antiprion drugs. The method allowed us to identify several compounds effective against budding yeast prions responsible for the [PSI+] and [URE3] phenotypes. These inhibitors include the kastellpaolitines, a new class of compounds, and two previously known molecules, phenanthridin...
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Isolation of drugs active against mammalian prions using a yeast-based screening assay
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TN_cdi_hal_primary_oai_HAL_hal_00020141v1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_00020141v1
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt855
