Cytokinesis failure triggers hippo tumor suppressor pathway activation
Cytokinesis failure triggers hippo tumor suppressor pathway activation
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Publisher
Tech Science Press
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Language
English
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Publisher
Tech Science Press
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Contents
Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ∼37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the cellular defects and corresponding signaling path...
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Full title
Cytokinesis failure triggers hippo tumor suppressor pathway activation
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Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_01085073v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01085073v1
Other Identifiers
ISSN
0327-9545
E-ISSN
1667-5746
DOI
10.1016/j.cell.2014.06.029
