Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s dise...
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits
About this item
Full title
Author / Creator
Lacampagne, Alain , Liu, Xiaoping , Reiken, Steven , Bussiere, Renaud , Meli, Albano C. , Lauritzen, Inger , Teich, Andrew F. , Zalk, Ran , Saint, Nathalie , Arancio, Ottavio , Bauer, Charlotte , Duprat, Fabrice , Briggs, Clark A. , Chakroborty, Shreaya , Stutzmann, Grace E. , Shelanski, Michael L. , Checler, Frederic , Chami, Mounia and Marks, Andrew R.
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 channels undergo post-translational remodeling (PKA phosphorylation, oxidation, and nitrosylation) in brains of AD patients, and in two murine models of AD (3 × Tg-AD,
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Alternative Titles
Full title
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits
Authors, Artists and Contributors
Author / Creator
Liu, Xiaoping
Reiken, Steven
Bussiere, Renaud
Meli, Albano C.
Lauritzen, Inger
Teich, Andrew F.
Zalk, Ran
Saint, Nathalie
Arancio, Ottavio
Bauer, Charlotte
Duprat, Fabrice
Briggs, Clark A.
Chakroborty, Shreaya
Stutzmann, Grace E.
Shelanski, Michael L.
Checler, Frederic
Chami, Mounia
Marks, Andrew R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_01832793v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01832793v1
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-017-1733-7
