Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
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Author / Creator
Routy, Bertrand , Le Chatelier, Emmanuelle , Derosa, Lisa , Duong, Connie P M , Alou, Maryam Tidjani , Daillère, Romain , Fluckiger, Aurélie , Messaoudene, Meriem , Rauber, Conrad , Roberti, Maria P , Fidelle, Marine , Flament, Caroline , Poirier-Colame, Vichnou , Opolon, Paule , Klein, Christophe , Iribarren, Kristina , Mondragón, Laura , Jacquelot, Nicolas , Qu, Bo , Ferrere, Gladys , Clémenson, Céline , Mezquita, Laura , Masip, Jordi Remon , Naltet, Charles , Brosseau, Solenn , Kaderbhai, Coureche , Richard, Corentin , Rizvi, Hira , Levenez, Florence , Galleron, Nathalie , Quinquis, Benoit , Pons, Nicolas , Ryffel, Bernhard , Minard-Colin, Véronique , Gonin, Patrick , Soria, Jean-Charles , Deutsch, Eric , Loriot, Yohann , Ghiringhelli, François , Zalcman, Gérard , Goldwasser, François , Escudier, Bernard , Hellmann, Matthew D , Eggermont, Alexander , Raoult, Didier , Albiges, Laurence , Kroemer, Guido and Zitvogel, Laurence
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition. Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer. Fecal microbiota trans...
Alternative Titles
Full title
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Authors, Artists and Contributors
Author / Creator
Le Chatelier, Emmanuelle
Derosa, Lisa
Duong, Connie P M
Alou, Maryam Tidjani
Daillère, Romain
Fluckiger, Aurélie
Messaoudene, Meriem
Rauber, Conrad
Roberti, Maria P
Fidelle, Marine
Flament, Caroline
Poirier-Colame, Vichnou
Opolon, Paule
Klein, Christophe
Iribarren, Kristina
Mondragón, Laura
Jacquelot, Nicolas
Qu, Bo
Ferrere, Gladys
Clémenson, Céline
Mezquita, Laura
Masip, Jordi Remon
Naltet, Charles
Brosseau, Solenn
Kaderbhai, Coureche
Richard, Corentin
Rizvi, Hira
Levenez, Florence
Galleron, Nathalie
Quinquis, Benoit
Pons, Nicolas
Ryffel, Bernhard
Minard-Colin, Véronique
Gonin, Patrick
Soria, Jean-Charles
Deutsch, Eric
Loriot, Yohann
Ghiringhelli, François
Zalcman, Gérard
Goldwasser, François
Escudier, Bernard
Hellmann, Matthew D
Eggermont, Alexander
Raoult, Didier
Albiges, Laurence
Kroemer, Guido
Zitvogel, Laurence
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_02126484v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02126484v1
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan3706
