Transcription-dependent regulation of replication dynamics modulates genome stability
Transcription-dependent regulation of replication dynamics modulates genome stability
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late in S phase, are cell-type specific and nest in large genes. The relative impact of transcription–replication conflicts versus a low density in initiation events on fragility is currently deba...
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Full title
Transcription-dependent regulation of replication dynamics modulates genome stability
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TN_cdi_hal_primary_oai_HAL_hal_02511509v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02511509v1
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-018-0170-1
