Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes, such as tryptase and chymase, at the cell–cell contact site. This previously...
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Full title
Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence
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TN_cdi_hal_primary_oai_HAL_hal_03533120v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03533120v1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7174
