Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfe...
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo
About this item
Full title
Author / Creator
Subramanian, Sethuraman , Busch, Clara Jana-Lui , Molawi, Kaaweh , Geirsdottir, Laufey , Maurizio, Julien , Vargas Aguilar, Stephanie , Belahbib, Hassiba , Gimenez, Gregory , Yuda, Ridzky Anis Advent , Burkon, Michaela , Favret, Jérémy , Gholamhosseinian Najjar, Sara , de Laval, Bérengère , Kandalla, Prashanth Kumar , Sarrazin, Sandrine , Alexopoulou, Lena and Sieweke, Michael H.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show that mouse long-term ex vivo expanded AMs (exAMs) maintained a core AM gene expression program, but showed culture adaptations related to adhesion, metabolism and prol...
Alternative Titles
Full title
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo
Authors, Artists and Contributors
Author / Creator
Busch, Clara Jana-Lui
Molawi, Kaaweh
Geirsdottir, Laufey
Maurizio, Julien
Vargas Aguilar, Stephanie
Belahbib, Hassiba
Gimenez, Gregory
Yuda, Ridzky Anis Advent
Burkon, Michaela
Favret, Jérémy
Gholamhosseinian Najjar, Sara
de Laval, Bérengère
Kandalla, Prashanth Kumar
Sarrazin, Sandrine
Alexopoulou, Lena
Sieweke, Michael H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03664920v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03664920v1
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-022-01146-w
