Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
About this item
Full title
Author / Creator
KEYNOTE-177 Investigators , André, Thierry , Shiu, Kai-Keen , Kim, Tae Won , Jensen, Benny Vittrup , Jensen, Lars Henrik , Punt, Cornelis , Smith, Denis , Garcia-Carbonero, Rocio , Benavides, Manuel , Gibbs, Peter , de la Fouchardiere, Christelle , Rivera, Fernando , Elez, Elena , Bendell, Johanna , Le, Dung T , Yoshino, Takayuki , Van Cutsem, Eric , Yang, Ping , Farooqui, Mohammed Z.H , Marinello, Patricia and Diaz, Luis A
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Colorectal cancer is genetically heterogeneous. Tumors in some patients have defects in mismatch DNA repair. These tumors have a high level of mutations that can lead to immune recognition. In a group of patients with microsatellite-unstable tumors, pembrolizumab led to longer progression-free survival and was less toxic than standard chemotherapy.
Alternative Titles
Full title
Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
Authors, Artists and Contributors
Author / Creator
André, Thierry
Shiu, Kai-Keen
Kim, Tae Won
Jensen, Benny Vittrup
Jensen, Lars Henrik
Punt, Cornelis
Smith, Denis
Garcia-Carbonero, Rocio
Benavides, Manuel
Gibbs, Peter
de la Fouchardiere, Christelle
Rivera, Fernando
Elez, Elena
Bendell, Johanna
Le, Dung T
Yoshino, Takayuki
Van Cutsem, Eric
Yang, Ping
Farooqui, Mohammed Z.H
Marinello, Patricia
Diaz, Luis A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04548018v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04548018v1
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2017699
