Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci...
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
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van Rheenen, Wouter , van der Spek, Rick a A , Bakker, Mark K , van Vugt, Joke J F A , Hop, Paul J , Zwamborn, Ramona a J , de Klein, Niek , Westra, Harm-Jan , Bakker, Olivier B , Deelen, Patrick , Shireby, Gemma , Hannon, Eilis , Moisse, Matthieu , Baird, Denis , Restuadi, Restuadi , Dolzhenko, Egor , Dekker, Annelot M , Gawor, Klara , Westeneng, Henk-Jan , Tazelaar, Gijs H P , van Eijk, Kristel R , Kooyman, Maarten , Byrne, Ross P , Doherty, Mark , Heverin, Mark , Al Khleifat, Ahmad , Iacoangeli, Alfredo , Shatunov, Aleksey , Ticozzi, Nicola , Cooper-Knock, Johnathan , Smith, Bradley N , Gromicho, Marta , Chandran, Siddharthan , Pal, Suvankar , Morrison, Karen E , Shaw, Pamela J , Hardy, John , Orrell, Richard W , Sendtner, Michael , Meyer, Thomas , Başak, Nazli , van der Kooi, Anneke J , Ratti, Antonia , Fogh, Isabella , Gellera, Cinzia , Lauria, Giuseppe , Corti, Stefania , Cereda, Cristina , Sproviero, Daisy , d'Alfonso, Sandra , Sorarù, Gianni , Siciliano, Gabriele , Filosto, Massimiliano , Padovani, Alessandro , Chiò, Adriano , Calvo, Andrea , Moglia, Cristina , Brunetti, Maura , Canosa, Antonio , Grassano, Maurizio , Beghi, Ettore , Pupillo, Elisabetta , Logroscino, Giancarlo , Nefussy, Beatrice , Osmanovic, Alma , Nordin, Angelica , Lerner, Yossef , Zabari, Michal , Gotkine, Marc , Baloh, Robert H , Bell, Shaughn , Vourc'H, Patrick , Corcia, Philippe , Couratier, Philippe , Millecamps, Stéphanie , Meininger, Vincent , Salachas, François , Mora Pardina, Jesus S , Assialioui, Abdelilah , Rojas-García, Ricardo , Dion, Patrick A , Ross, Jay P , Ludolph, Albert C , Weishaupt, Jochen H , Brenner, David , Freischmidt, Axel , Bensimon, Gilbert , Brice, Alexis , Durr, Alexandra , Payan, Christine a M , Saker-Delye, Safa , Wood, Nicholas W , Topp, Simon , Rademakers, Rosa , Tittmann, Lukas , Lieb, Wolfgang , Franke, Andre , Ripke, Stephan , Braun, Alice and Kraft, Julia
Publisher
Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
Nature Publishing Group
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More information
Scope and Contents
Contents
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 indi...
Alternative Titles
Full title
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Authors, Artists and Contributors
Author / Creator
van der Spek, Rick a A
Bakker, Mark K
van Vugt, Joke J F A
Hop, Paul J
Zwamborn, Ramona a J
de Klein, Niek
Westra, Harm-Jan
Bakker, Olivier B
Deelen, Patrick
Shireby, Gemma
Hannon, Eilis
Moisse, Matthieu
Baird, Denis
Restuadi, Restuadi
Dolzhenko, Egor
Dekker, Annelot M
Gawor, Klara
Westeneng, Henk-Jan
Tazelaar, Gijs H P
van Eijk, Kristel R
Kooyman, Maarten
Byrne, Ross P
Doherty, Mark
Heverin, Mark
Al Khleifat, Ahmad
Iacoangeli, Alfredo
Shatunov, Aleksey
Ticozzi, Nicola
Cooper-Knock, Johnathan
Smith, Bradley N
Gromicho, Marta
Chandran, Siddharthan
Pal, Suvankar
Morrison, Karen E
Shaw, Pamela J
Hardy, John
Orrell, Richard W
Sendtner, Michael
Meyer, Thomas
Başak, Nazli
van der Kooi, Anneke J
Ratti, Antonia
Fogh, Isabella
Gellera, Cinzia
Lauria, Giuseppe
Corti, Stefania
Cereda, Cristina
Sproviero, Daisy
d'Alfonso, Sandra
Sorarù, Gianni
Siciliano, Gabriele
Filosto, Massimiliano
Padovani, Alessandro
Chiò, Adriano
Calvo, Andrea
Moglia, Cristina
Brunetti, Maura
Canosa, Antonio
Grassano, Maurizio
Beghi, Ettore
Pupillo, Elisabetta
Logroscino, Giancarlo
Nefussy, Beatrice
Osmanovic, Alma
Nordin, Angelica
Lerner, Yossef
Zabari, Michal
Gotkine, Marc
Baloh, Robert H
Bell, Shaughn
Vourc'H, Patrick
Corcia, Philippe
Couratier, Philippe
Millecamps, Stéphanie
Meininger, Vincent
Salachas, François
Mora Pardina, Jesus S
Assialioui, Abdelilah
Rojas-García, Ricardo
Dion, Patrick A
Ross, Jay P
Ludolph, Albert C
Weishaupt, Jochen H
Brenner, David
Freischmidt, Axel
Bensimon, Gilbert
Brice, Alexis
Durr, Alexandra
Payan, Christine a M
Saker-Delye, Safa
Wood, Nicholas W
Topp, Simon
Rademakers, Rosa
Tittmann, Lukas
Lieb, Wolfgang
Franke, Andre
Ripke, Stephan
Braun, Alice
Kraft, Julia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04777606v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04777606v1
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00973-1
