Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label,...
Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial
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Author / Creator
Wang, Eunice S, Prof , Issa, Ghayas C, MD , Erba, Harry P, Prof , Altman, Jessica K, Prof , Montesinos, Pau, MD , DeBotton, Stephane, MD , Walter, Roland B, Prof , Pettit, Kristen, MD , Savona, Michael R, Prof , Shah, Mithun Vinod, MD , Kremyanskaya, Marina, MD , Baer, Maria R, Prof , Foran, James M, Prof , Schiller, Gary, Prof , Adès, Lionel, Prof , Heiblig, Mael, MD , Berthon, Celine, MD , Peterlin, Pierre, MD , Rodríguez-Arbolí, Eduardo, MD , Salamero, Olga, MD , Patnaik, Mrinal M, Prof , Papayannidis, Cristina, MD , Grembecka, Jolanta, Prof , Cierpicki, Tomasz, Prof , Clegg, Bradley, BA , Ray, Joshua, BSc , Linhares, Brian M, PhD , Nie, Kun, PhD , Mitra, Amitava, PhD , Ahsan, Julie Mackey, MS , Tabachri, Marilyn, BSN , Soifer, Harris S, PhD , Corum, Daniel, PhD , Leoni, Mollie, MD , Dale, Stephen, MD and Fathi, Amir T, MD
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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More information
Scope and Contents
Contents
SummaryBackgroundZiftomenib (KO-539) is an oral selective menin inhibitor with known preclinical activity in menin-dependent acute myeloid leukaemia models. The primary objective of this study was to determine the recommended phase 2 dose in patients with relapsed or refractory acute myeloid leukaemia based on safety, pharmacokinetics, pharmacodyna...
Alternative Titles
Full title
Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial
Authors, Artists and Contributors
Author / Creator
Issa, Ghayas C, MD
Erba, Harry P, Prof
Altman, Jessica K, Prof
Montesinos, Pau, MD
DeBotton, Stephane, MD
Walter, Roland B, Prof
Pettit, Kristen, MD
Savona, Michael R, Prof
Shah, Mithun Vinod, MD
Kremyanskaya, Marina, MD
Baer, Maria R, Prof
Foran, James M, Prof
Schiller, Gary, Prof
Adès, Lionel, Prof
Heiblig, Mael, MD
Berthon, Celine, MD
Peterlin, Pierre, MD
Rodríguez-Arbolí, Eduardo, MD
Salamero, Olga, MD
Patnaik, Mrinal M, Prof
Papayannidis, Cristina, MD
Grembecka, Jolanta, Prof
Cierpicki, Tomasz, Prof
Clegg, Bradley, BA
Ray, Joshua, BSc
Linhares, Brian M, PhD
Nie, Kun, PhD
Mitra, Amitava, PhD
Ahsan, Julie Mackey, MS
Tabachri, Marilyn, BSN
Soifer, Harris S, PhD
Corum, Daniel, PhD
Leoni, Mollie, MD
Dale, Stephen, MD
Fathi, Amir T, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04922787v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04922787v1
Other Identifiers
ISSN
1470-2045,1474-5488
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(24)00386-3
