Log in to save to my catalogue

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T c...

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T c...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_00484154v1

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

About this item

Full title

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Publisher

New York: Nature Publishing Group US

Journal title

Nature immunology, 2008-06, Vol.9 (6), p.632-640

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

The molecular mechanisms directing the development of 'natural' CD4
+
CD25
+
Foxp3
+
regulatory T cells (T
reg
cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-β receptor I (TβRI) in T cells blocked the appearance of CD4
+
CD25
+
Foxp3
+

Alternative Titles

Full title

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_hal_primary_oai_HAL_inserm_00484154v1

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_00484154v1

Other Identifiers

ISSN

1529-2908

E-ISSN

1529-2916

DOI

10.1038/ni.1607

How to access this item