Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and...
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects
About this item
Full title
Author / Creator
Scekic-Zahirovic, Jelena , Sanjuan-Ruiz, Inmaculada , Kan, Vanessa , Megat, Salim , de Rossi, Pierre , Dieterlé, Stéphane , Cassel, Raphaelle , Jamet, Marguerite , Kessler, Pascal , Wiesner, Diana , Tzeplaeff, Laura , Demais, Valérie , Sahadevan, Sonu , Hembach, Katharina , Muller, Hans-Peter , Picchiarelli, Gina , Mishra, Nibha , Antonucci, Stefano , Dirrig-Grosch, Sylvie , Kassubek, Jan , Rasche, Volker , Ludolph, Albert , Boutillier, Anne-Laurence , Roselli, Francesco , Polymenidou, Magdalini , Lagier-Tourenne, Clotilde , Liebscher, Sabine and Dupuis, Luc
Publisher
Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is also observed in other diseases, with unknown consequences. Here, we show that cytoplasmic mislocalization of FUS drives behavioral abnormalities in knock-in mice, includin...
Alternative Titles
Full title
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects
Authors, Artists and Contributors
Author / Creator
Sanjuan-Ruiz, Inmaculada
Kan, Vanessa
Megat, Salim
de Rossi, Pierre
Dieterlé, Stéphane
Cassel, Raphaelle
Jamet, Marguerite
Kessler, Pascal
Wiesner, Diana
Tzeplaeff, Laura
Demais, Valérie
Sahadevan, Sonu
Hembach, Katharina
Muller, Hans-Peter
Picchiarelli, Gina
Mishra, Nibha
Antonucci, Stefano
Dirrig-Grosch, Sylvie
Kassubek, Jan
Rasche, Volker
Ludolph, Albert
Boutillier, Anne-Laurence
Roselli, Francesco
Polymenidou, Magdalini
Lagier-Tourenne, Clotilde
Liebscher, Sabine
Dupuis, Luc
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_inserm_03376335v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_inserm_03376335v1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23187-9
