Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population A Genome-Wide Evaluation of 13 974 Participants in the Women’s Genome Health Study
Guillaume Paré, MD, MSc, FRCP(C) * ;
Daniel I. Chasman, PhD * ;
Alexander N. Parker, PhD ;
Robert R.Y. Zee, PhD, MPH ;
Anders Mälarstig, PhD ;
Udo Seedorf, PhD ;
Rory Collins, MBBS, MSc, FRCP ;
Hugh Watkins, MD, PhD, FRCP ;
Anders Hamsten, MD, PhD, FRCP ;
Joseph P. Miletich, MD and
Paul M Ridker, MD, MPH
From the Center for Cardiovascular Disease Prevention (G.P., D.I.C., R.R.Y.Z., P.M.R.) and the Donald W. Reynolds Center for Cardiovascular Research (G.P., D.I.C., R.R.Y.Z., P.M.R.), Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass; Amgen, Inc (A.N.P., J.P.M.), Cambridge, Mass; Atherosclerosis Research Unit (A.M., A.H.), Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Leibniz-Institut für Arterioskleroseforschung an der Universität Münster (U.S.), Münster, Germany; Clinical Trial Service Unit and Epidemiological Studies Unit (R.C.), and Department of Cardiovascular Medicine (H.W.), University of Oxford, Oxford, United Kingdom; and the PROCARDIS Consortium, www.procardis.org.
Correspondence to Guillaume Paré, MD, Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, 900 Commonwealth Ave East, 3rd Floor, Boston, MA 02215. E-mail gpare{at}rics.bwh.harvard.edu
Received October 20, 2008; accepted February 9, 2009.
Background— Homocysteine is a sulfur amino acid whose plasma concentration...

Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population: A Genome-Wide Evaluation of 13 974 Participants in the Women's Genome Health Study

10.1161/CIRCGENETICS.108.829804