Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
Hui-Qi Qu 1 ,
Struan F.A. Grant 2 3 ,
Jonathan P. Bradfield 2 ,
Cecilia Kim 2 ,
Edward Frackelton 2 ,
Hakon Hakonarson 2 3 and
Constantin Polychronakos 1
1 Departments of Pediatrics and Human Genetics, McGill University, Montreal, Québec, Canada
2 Center for Applied Genomics, Philadelphia, Pennsylvania
3 Department of Pediatrics and Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Corresponding authors: Hakon Hakonarson, hakonarson{at}chop.edu , and Constantin Polychronakos, constantin.polychronakos{at}mcgill.ca
Abstract
OBJECTIVE— To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG , KCNJ11 , WFS1 , HNF1B , IDE / HHEX , SLC30A8 , CDKAL1 , CDKN2A / B , IGF2BP2 , and FTO / RPGRIP1L .
RESEARCH DESIGN AND METHODS— Two European population samples were studied: 1 ) one case-control cohort of 514 type 1 diabetic subjects and 2,027 control subjects and 2 ) one family cohort of 483 complete type 1 diabetic case-parent trios (total 997 affected). A total of 13 tag single nucleotide
polymorphisms (SNPs) from the 10 type 2 diabetes loci were analyzed for type 1 diabetes association.
RESULTS— No association of type 1 diabetes was found with any of the 10 type 2 diabetes loci, and no age-at-onset effect was detected.
By combined analysis using the Wellcome Trust Case-Control Consortium type 1 diabetes data, SNP rs1412829 in the CDKN2A/B locus bordered on significance ( P = 0.039) (odds ratio 0.929 [95% CI 0.867–0.995]), which did not reach the statistical significance threshold adjusted for
13 tests (α = 0.00385).
CONCLUSIONS— This study suggests that the type 2 diabetes loci do not play any obvious role in type 1 diabetes genetic susceptibility.
The distinct molecular mechanisms of the two diseases highlighted the importance of differentiation diagnosis and different
treatment principles.
Footnotes
Published ahead of print at http://diabetes.diabetesjournals.org on 21 April 2008.
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Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes

10.2337/db08-0270