In Vitro Activation of Peroxisome Proliferator Activated Receptor α by Some Extracts from Food Mater...
In Vitro Activation of Peroxisome Proliferator Activated Receptor α by Some Extracts from Food Materials
About this item
Full title
In Vitro Activation of Peroxisome Proliferator Activated Receptor α by Some Extracts from Food Materials
Author / Creator
Publisher
台灣: 衛生福利部食品藥物管理署
Journal title
藥物食品分析, 2008-08, Vol.16 (4), p.62-69
Language
Chinese
Formats
Publication information
Publisher
台灣: 衛生福利部食品藥物管理署
Subjects
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Scope and Contents
Contents
過氧化體增殖劑活化受器α(PPARα)是屬於依賴配體活化之轉錄因子，能調節與脂質代謝有關基因之表現。已知PPARα之活化劑可能具有降血脂之潛力，如同fibrate類之降血脂藥的作用。因此本研究之目的欲從日常之食材中篩選出具降血脂功能潛力之PPARα活化劑。實驗採用穩定轉染之方式成功地將受器基因及報導基因質體轉染至CHO-K1細胞。篩選出來之細胞株對於PPARα已知之活化劑Wy-14643有最佳之活化反應，可藉此作?測試食材中是否具有PPARα活化潛力成分之篩選工具。食材用乙酸乙酯萃取並進行冷皂化反應，然後以篩選出來之細胞株進行活化能力測試並以Wy-14643(10μM)當作正對照。在所有測試之食材當中以苦瓜之乙酸乙酯萃取物具有最佳之活化能力甚至超過正對照Wy-14643。而洋蔥乙酸乙酯萃取物...
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Full title
In Vitro Activation of Peroxisome Proliferator Activated Receptor α by Some Extracts from Food Materials
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Author / Creator
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Record Identifier
TN_cdi_hyweb_hyread_00034731
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hyweb_hyread_00034731
Other Identifiers
ISSN
1021-9498
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