Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Do...
Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Full-length amyloid beta peptides (Aβ₁₋₄₀/₄₂) form neuritic amyloid plaques in Alzheimer's disease (AD) patients and are implicated in AD pathology. However, recent transgenic animal models cast doubt on their direct role in AD pathology. Nonamyloidogenic truncated amyloid-beta fragments (Aβ₁₁₋₄₂ and Aβ₁₇₋₄₂) are also found in amyloid plaques of AD...
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Full title
Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome
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TN_cdi_jstor_primary_25665204
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25665204
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.0914251107
