Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
About this item
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Author / Creator
Publisher
National Academy of Sciences
Journal title
Language
English
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Publisher
National Academy of Sciences
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Scope and Contents
Contents
Although a key factor in Alzheimer's disease etiology is enrichment of Zn²⁺ in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn²⁺-Aβ coordination promotes aggregation is elusive. Here we probe the structures and mechanisms through which Zn²⁺ can affect amyloidosis. By covalently linking fragments (that have experimen...
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Full title
Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Authors, Artists and Contributors
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TN_cdi_jstor_primary_25681626
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_25681626
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0913114107
