Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
TREX1 is an exonuclease that digests DNA in the cytoplasm. Loss-of-function mutations of TREX1 are linked to Aicardi–Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE) in humans.Trex1−/−
mice exhibit autoimmune and inflammatory phenotypes that are associated with elevated expression of interferon (IFN)-induced genes (ISGs). Cyclic G...
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Full title
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
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TN_cdi_jstor_primary_26465582
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26465582
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1516465112
