α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human...
α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the accumulation of protein aggregates comprised of α-synuclein (α-syn). A major barrier in treatment discovery for PD is the lack of identifiable therapeutic pathways capable of reducing aggregates in human neuronal model systems. Mutations in key components of...
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Full title
α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
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TN_cdi_jstor_primary_26467761
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_jstor_primary_26467761
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1520335113
